01 - Mix mayonnaise, Dijon mustard, relish, hot sauce, lemon juice, minced garlic, smoked paprika, salt, and pepper in a small bowl. Chill until ready to use.
02 - In a shallow bowl, whisk together flour, cornmeal, Cajun seasoning, garlic powder, paprika, salt, and black pepper.
03 - In another bowl, whisk eggs and milk together until fully combined.
04 - Dip each shrimp first in the egg mixture, then dredge in the flour-cornmeal mixture, pressing lightly to ensure an even coating.
05 - Heat about 2 inches of vegetable oil in a large skillet or Dutch oven to 350°F.
06 - Fry shrimp in batches for 2-3 minutes per side, until golden brown and crispy. Drain on paper towels.
07 - Lightly toast the rolls if desired, then spread remoulade sauce generously on both sides of each roll.
08 - Layer shredded lettuce, tomato slices, pickles, and fried shrimp onto each roll. Top with extra sauce if desired.
09 - Serve the po boy sandwiches immediately while the shrimp are hot and crispy.